Vasoactive Intestinal Peptide (VIP)
Also known as: VIP
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide of the secretin/glucagon family, widely distributed in the CNS and peripheral nervous system. It is a potent vasodilator, bronchodilator, and immunomodulator. Synthetic VIP (aviptadil) has been investigated in clinical trials for COVID-19-associated acute respiratory failure; it is NOT FDA-approved. Intranasal compounded VIP is used off-label in the controversial 'CIRS' (Chronic Inflammatory Response Syndrome) / mold-illness protocol popularized by Ritchie Shoemaker — CIRS is not a mainstream medical diagnosis.
Who's worth your money for Vasoactive Intestinal Peptide (VIP)
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 11 scored sellers
$990 · 200mg · 99.4% purity
Most tested
5 independent COAs on file
$74.97 · 5mg · 99.7% purity
Average price
$8.03/mg
Sellers
20
45-day trend
+2.8%
19 of 20 sellers have a current price· 6 stale hidden· 2 unverified hidden
Top Merit pick
🇺🇸 Peptide Partners99via Disclosed Labs · 10h ago
$4.95/mg -38.3% vs avg$990
200mg
- 🇺🇸 BioLongevity Labs96
via Disclosed Labs · 10h ago
$14.99/mg +86.8% vs avg$74.97
5mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 10h ago
$6.00/mg -25.3% vs avg$60.00
10mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 10h ago
$9.00/mg +12.1% vs avg$89.99
10mg
no purityBuy Code Orbitrex10 · 10% off - 🇺🇸 NG Peptide86
via Disclosed Labs · 10h ago
$4.50/mg -43.9% vs avg$45.00
10mg
no purity - 🇺🇸 Simple Peptide85
via Disclosed Labs · 10h ago
$10.40/mg +29.5% vs avg$52.00
5mg
- Peptide Supply Co.83
via Disclosed Labs · 10h ago
$4.50/mg -43.9% vs avg$450
100mg
no purity - Modern Research Peptides82
via Disclosed Labs · 10h ago
$6.00/mg -25.3% vs avg$59.99
10mg
no purity - True Peptide82
via Disclosed Labs · 10h ago
$12.00/mg +49.5% vs avg$60.00
5mg
no purityBuy Code MERIT · 15% off - 🇺🇸 Blank Peptides81
via Disclosed Labs · 10h ago
$7.50/mg -6.6% vs avg$75.00
10mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Vasoactive Intestinal Peptide (VIP)
CAS
40077-57-4
Molecular formula
C147H237N43O43S
Sequence
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Typical dose range
50 mcg per nostril (400 mcg/day) intranasal 4x daily (Shoemaker/CIRS protocol); 25–50 mcg/kg inhaled q4–6h for pulmonary research
Half-life
~1–2 minutes (plasma, IV/physiological conditions)
COAs for Vasoactive Intestinal Peptide (VIP)
19 third-party tests across 9 vendors. Each card links to the full report.
For
Vasoactive Intestinal Peptide (VIP)
by Crush Research· batch CRVIP-10-2604-1
For
Vasoactive Intestinal Peptide (VIP)
by Simple Peptide· batch VP5-032026-1
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-46041
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
For
Vasoactive Intestinal Peptide (VIP)
by Glacier Aminos· batch VIP10GA01
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-45951
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch cmojb76ku0193kirx6m3i9gri
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
For
Vasoactive Intestinal Peptide (VIP)
by Peptide Partners· batch VP20250511
For
Vasoactive Intestinal Peptide (VIP)
by Profound Aminos· batch 2025-05-19
For
Vasoactive Intestinal Peptide (VIP)
by Verified Peptides· batch cmojb6azj012wkirxcsj3o26v
For
Vasoactive Intestinal Peptide (VIP)
by Glacier Aminos· batch VIP10GA-02
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Mile High Compounds· batch VIP-010-MH-01
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch 31-3-45951
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by BioLongevity Labs· batch cmojb76h30192kirxwdp6g317
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Skye Peptides· batch VIP25-05-002
Purity not on file
For
Vasoactive Intestinal Peptide (VIP)
by Peptide Partners· batch cmojb223b003fkirx4s4gkb1s
20 citations indexed for Vasoactive Intestinal Peptide (VIP)
case-report · 2026
Vasoactive Intestinal Peptide (VIP)-Secreting Neuroblastic Tumors in Children Presenting With Chronic Secretory Diarrhea: A Report of Two Cases
Vasoactive intestinal peptide (VIP)-secreting neuroblastic tumors are rare pediatric neoplasms that may present with chronic secretory diarrhea prior to tumor detection, posing significant diagnostic and therapeutic challenges.
rct · 2026
Study on Neostigmine Acupoint Injection at Zusanli(ST36) for Treating Mechanical Ventilation-Associated Gastrointestinal Dysfunction
Mechanical ventilation is a common method of respiratory support for critically ill patients, and gastrointestinal dysfunction (GIDF) is a frequent complication. In the ICU, more than 60% of mechanically ventilated patients experience gastrointestinal dysfunction.
Study · 2025
Vasoactive Intestinal Peptide (VIP) in COVID-19 Therapy-Shedding of ACE2 and TMPRSS2 via ADAM10
Patients infected with SARS-CoV-2 may develop mild respiratory symptoms but also Acute Respiratory Distress Syndrome (ARDS). Additionally, severe systemic inflammation contributes to morbidity and mortality.
animal · 2025
Vasoactive Intestinal Peptide (VIP) and its Receptors in Adipose Tissue: Implications for Cold Stress Adaptation
Adipose tissue represents an organ that is highly dynamic and contributes toward vital survival events such as immune responses, lactation, metabolism fuel, and thermogenesis.
rct · 2025
Efficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
The goal of this clinical trial is to learn if Stapokibart (CM310) works to treat Non-Allergic Rhinitis with Eosinophilia Syndrome (NARES) in adults. It will also learn about the safety of CM310. The main questions it aims to answer are: Does drug CM310 relieve the symptoms of participants?
Study · 2024
Increased Vasoactive Intestinal Peptide (VIP) in polycystic ovary syndrome patients undergoing IVF
Introduction Polycystic ovary syndrome (PCOS) is a common multifactorial and polygenic disorder of the endocrine system, affecting up to 20% of women in reproductive age with a still unknown etiology.