Syn-Ake
Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate, SYN-AKE, beta-Ala-Pro-Dab-NHBn diacetate
Synthetic cosmetic dipeptide (beta-alanyl-prolyl-diaminobutyroyl benzylamide, supplied as the diacetate salt) developed by Pentapharm/DSM to mimic Waglerin-1, a component of temple viper (Tropidolaemus wagleri) venom. It acts as a reversible antagonist of the muscle-type (m) nicotinic acetylcholine receptor, reducing repeated muscle contraction to soften expression wrinkles in a topical, Botox-mimetic fashion. It is a topical cosmetic ingredient, not a therapeutic drug, and has no FDA drug approval; cosmetic anti-wrinkle claims rest mainly on manufacturer studies. The diacetate salt molecular formula is C23H37N5O7 (active dipeptide core C19H29N5O3).
Who's worth your money for Syn-Ake
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (86) of 1 scored sellers
$85.00 · 200mg
Average price
$0.65/mg
Sellers
7
45-day trend
+23.4%
4 of 7 sellers have a current price· 3 unverified hidden
- 🇺🇸 Verified Peptides86
✓ verified at source · 23h ago
$0.42/mg -34.6% vs avg$85.00
200mg
no purity
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Syn-Ake
CAS
823202-99-9
Molecular formula
C23H37N5O7
Typical dose range
Topical only; formulated at ~1-4% of a 0.05% peptide trade solution in finished cosmetics (no systemic/injectable dosing)
Half-life
Not characterized for systemic exposure; used topically as a cosmetic, not administered systemically
Common research uses
Safety notes
Topical cosmetic ingredient, not an FDA-approved drug; efficacy evidence is largely manufacturer-derived. Generally regarded as well tolerated topically, but not evaluated for systemic or injectable use, which is unsafe and outside its intended use. Not a WADA-listed substance.
Reconstitution
Supplied as a water-soluble cosmetic raw material; incorporated into the aqueous phase of topical formulations. Not intended for reconstitution as an injectable.
COAs for Syn-Ake
1 third-party test across 1 vendor. Each card links to the full report.
12 citations indexed for Syn-Ake
review · 2025
Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy
Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration.
Study · 2025
Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties
Objectives Skin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage.
in-vitro · 2025
In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution
Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis.
review · 2025
Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers
Today's consumer perception and expectations of personal care have gone beyond merely cleansing, moisturizing, and makeup products, focusing more on the reduction or elimination of signs of aging.
review · 2025
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products.
Study · 2024
Anti-aging activity of Syn-Ake peptide by <i>in silico</i> approaches and <i>in vitro</i> tests
The increase in the aging population worldwide has led scientists to turn to research to prevent the aging process. In this context, synthetic peptides emerge as candidate molecules for developing new anti-aging products.