Syn-Ake
Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate, SYN-AKE, beta-Ala-Pro-Dab-NHBn diacetate
Synthetic cosmetic dipeptide (beta-alanyl-prolyl-diaminobutyroyl benzylamide, supplied as the diacetate salt) developed by Pentapharm/DSM to mimic Waglerin-1, a component of temple viper (Tropidolaemus wagleri) venom. It acts as a reversible antagonist of the muscle-type (m) nicotinic acetylcholine receptor, reducing repeated muscle contraction to soften expression wrinkles in a topical, Botox-mimetic fashion. It is a topical cosmetic ingredient, not a therapeutic drug, and has no FDA drug approval; cosmetic anti-wrinkle claims rest mainly on manufacturer studies. The diacetate salt molecular formula is C23H37N5O7 (active dipeptide core C19H29N5O3).
Who's worth your money for Syn-Ake
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (86) of 2 scored sellers
$85.00 · 200mg
Best value after code
$0.22/mg effective with 10% code
$49.00 · 200mg
Average price
$0.65/mg
Sellers
7
45-day trend
-2.5%
4 of 7 sellers have a current price· 2 unverified hidden
Top Merit pick
🇺🇸 Verified Peptides86✓ verified at source · 1h ago
$0.42/mg -34.6% vs avg$85.00
200mg
no purity- S1 Research37
✓ verified at source · just now
$0.24/mg -62.3% vs avg$49.00
200mg
no purityBuy Code merit · 10% off
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About Syn-Ake
CAS
823202-99-9
Molecular formula
C23H37N5O7
Typical dose range
Topical only; formulated at ~1-4% of a 0.05% peptide trade solution in finished cosmetics (no systemic/injectable dosing)
Half-life
Not characterized for systemic exposure; used topically as a cosmetic, not administered systemically
Common research uses
Safety notes
Topical cosmetic ingredient, not an FDA-approved drug; efficacy evidence is largely manufacturer-derived. Generally regarded as well tolerated topically, but not evaluated for systemic or injectable use, which is unsafe and outside its intended use. Not a WADA-listed substance.
Reconstitution
Supplied as a water-soluble cosmetic raw material; incorporated into the aqueous phase of topical formulations. Not intended for reconstitution as an injectable.
COAs for Syn-Ake
1 third-party test across 1 vendor. Each card links to the full report.
12 citations indexed for Syn-Ake
in-vitro · 2026
Development of cosmeceutical nanoemulsion formulation containing peptide acting on neurotransmitters and evaluation of its efficacy
External factors such as oxidative stress and ultraviolet (UV) radiation increase reactive oxygen species (ROS) and cause the skin to age faster. Recently, peptides have been frequently preferred in nanoformulation development to prevent these effects.
Study · 2026
NoTox Tweakments: Evidence for Topical Neurocosmetic Peptides as Needle‐Free Neuromodulators for Facial Wrinkle Reduction—A Systematic Review
Study · 2026
Prolonging the Efficacy of Botulinum Toxin A Using a Novel Toxin Mimetic Complex and Peptide Formulation
Study · 2026
Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications
Skin aging arises from intrinsic and extrinsic factors that drive extracellular matrix degradation, particularly of collagen and elastin, leading to wrinkles, pigmentation, and loss of skin elasticity.
Study · 2026
A novel all-in-one dynamic wrinkle evaluation system: Development, validation and application in cosmetic industries
Objective This study aimed to develop and validate a novel, integrated dynamic wrinkle assessment system based on standardized, real-time and multi-angle facial images and video recordings, and to explore its potential application in evaluating the anti-wrinkle efficacy of skincare products.
review · 2025
Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy
Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration.