SS-31 + MOTS-c
Also known as: Elamipretide + MOTS-c blend, Mitochondrial peptide stack
Pre-mixed blend of two mitochondria-targeted peptides marketed for cellular energy and metabolic support. SS-31 (elamipretide) is a tetrapeptide that concentrates in the inner mitochondrial membrane and binds cardiolipin, stabilizing cristae structure, reducing oxidative stress, and supporting ATP production. MOTS-c is a mitochondrial-derived peptide that activates AMPK metabolic signaling and influences glucose and lipid handling. SS-31 itself gained a narrow FDA approval (Forzinity, 2025) for Barth syndrome, but MOTS-c remains a research compound, and there is no controlled human efficacy or safety data for this specific combination — the blend is sold grey-market, not as the approved indication.
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About SS-31 + MOTS-c
CAS
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Molecular formula
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Typical dose range
Vendor-dependent; component norms: SS-31 commonly 5-25 mg/day subcutaneous in research/clinical use; MOTS-c 5-10 mg 1-3x/week subcutaneous. No validated combination dosing exists.
Half-life
SS-31: terminal half-life roughly 3-6 hours (subcutaneous, human clinical data); MOTS-c: short, not well characterized in humans
Common research uses
Safety notes
This blend is not FDA-approved; it is sold as a research-only / grey-market product. SS-31 is FDA-approved only as Forzinity for Barth syndrome, not as a general metabolic or anti-aging agent and not in combination with MOTS-c. No combination-specific human safety data. Not evaluated by WADA as a blend.
Reconstitution
Reconstitute lyophilized powder with bacteriostatic water; refrigerate after reconstitution.
COAs for SS-31 + MOTS-c
3 third-party tests across 1 vendor. Each card links to the full report.
For
SS-31/MOTS-c
by OROS Research· batch OR-LPSSMC20-526-B3
For
SS-31/MOTS-c
by OROS Research· batch OR-LPSSMC20-526-B2
For
SS-31/MOTS-c
by OROS Research· batch OR-LPSSMC20-326-B1