Retatrutide
Also known as: Retatrutide (LY3437943 — GLP-1/GIP/Glucagon triple agonist)
Retatrutide (Eli Lilly code LY3437943) is an investigational triple-receptor agonist simultaneously targeting GLP-1, GIP, and glucagon receptors. It is research-only and NOT FDA-approved as of April 2026; the Phase 3 TRIUMPH program is ongoing with anticipated NDA filing in 2026. Published Phase 2 data showed roughly 24% mean body weight loss at 48 weeks on 12 mg weekly (Jastreboff, NEJM 2023).
Who's worth your money for Retatrutide
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (95) of 16 scored sellers
$239 · 60mg · 99.8% purity
Best value
Lowest $/mg among scored sellers
$10.00 · 10mg · 99.8% purity
Most tested
31 independent COAs on file
$296 · 60mg · 99.8% purity
Average price
$7.83/mg
Sellers
82
45-day trend
+5.1%
71 of 82 sellers have a current price· 44 stale hidden· 11 unverified hidden
Top Merit pick
🇺🇸 Reta One Labs95via Disclosed Labs · 23h ago
$3.98/mg -49.1% vs avg$239
60mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 23h ago
$4.93/mg -37% vs avg$296
60mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 23h ago
$5.56/mg -29% vs avg$200
36mg
- 🇺🇸 Prime Peptides95
via Disclosed Labs · 23h ago
$7.50/mg -4.2% vs avg$450
60mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · 23h ago
$33.68/mg +330.4% vs avg$2021
60mg
- 🇺🇸 Forge Performance Co.94
✓ verified at source · 23h ago
$16.00/mg +104.5% vs avg$160
10mg
- 🇺🇸 Riptide Wellness92
via Disclosed Labs · 23h ago
$5.80/mg -25.9% vs avg$290
50mg
no purity - 🇺🇸 Sunrise Bioresearch88
via Disclosed Labs · 23h ago
$2.00/mg -74.5% vs avg$399
200mg
- 🇺🇸 Simple Peptide85
via Disclosed Labs · 23h ago
$7.48/mg -4.4% vs avg$359
48mg
- Peptide Supply Co.83
via Disclosed Labs · 23h ago
$1.33/mg -83% vs avg$800
600mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Retatrutide
CAS
2381089-83-2
Molecular formula
C221H342N46O68
Sequence
YXQGTFTSDYSIXLDKKAQXAFIEYLLEGGPSSGAPPPS
Typical dose range
0.5–12 mg once weekly subcutaneous (Phase 2 titration; 2–8 mg most studied maintenance range)
Half-life
~6 days
COAs for Retatrutide
442 third-party tests across 46 vendors. Each card links to the full report.
For
Retatrutide
by Peptide Plugs· batch 101-01-ZB
For
Retatrutide
by NG Peptide· batch RT20-09
For
Retatrutide
by Aspire Peptides· batch RT20-032026-1
For
Retatrutide
by Aspire Peptides· batch RT15-032026-1
For
Retatrutide
by Aspire Peptides· batch GLP-3R
For
Retatrutide
by Arcane Peptides· batch RT103
For
Retatrutide
by Moglabs· batch RT103
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Retatrutide
by EZ Peptides· batch EZP-3P1206222026-03
For
Retatrutide
by Peptide Partners· batch RTT2613
For
Retatrutide
by EZ Peptides· batch EZP-3P1206222026-03
For
Retatrutide
by Virtus Peptides· batch RT30-655
For
Retatrutide
by Virtus Peptides· batch RT10-655
For
Retatrutide
by Optima Supply· batch OS-2026-1258
For
Retatrutide
by Hydro Research Peptides· batch HR-2026-2051
For
Retatrutide
by Profound Aminos· batch White Cap
For
Retatrutide
by NG Peptide· batch rt30-6174
For
Retatrutide
by Forge Performance Co.· batch Clear Blue Cap
For
Retatrutide
by EZ Peptides· batch EZP-3P2005222026-02
For
Retatrutide
by EZ Peptides· batch EZP-3P2005222026-02
For
Retatrutide
by EZ Peptides· batch EZP-3P2005222026-02
For
Retatrutide
by EZ Peptides· batch EZP-3P2005220226-02
For
Retatrutide
by Peptide Plugs· batch 126-01-SM
For
Retatrutide
by Peptide Plugs· batch 129-01-DK
For
Retatrutide
by Peptide Plugs· batch 124-03-SM
23 citations indexed for Retatrutide
animal · 2026
Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats
Diabetes mellitus is associated with cognitive impairment and neurodegenerative changes, partly through hyperglycaemia-driven neuroinflammation and disrupted neuronal signalling.
review · 2026
Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Introduction It has been reported that glucagon-like peptide-1 (GLP-1) agonists or dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists exert beneficial effects on blood pressure and lipid profile.
rct · 2026
Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial
Background Retatrutide is a GIP, GLP-1, and glucagon triple hormone receptor agonist, under clinical development for type 2 diabetes, obesity, and related complications.
Study · 2026
Retatrutide and the urinary tract infection signal: Is the answer hidden in timing?
Study · 2026
A Hydrophobic Tag-Assisted Liquid-Phase Strategy for the Synthesis of Retatrutide
Retatrutide is a novel triple agonist that targets the glucagon receptor (GCGR), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon-like peptide-1 receptor (GLP-1R).
Study · 2026
Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease
Background and hypothesis Retatrutide is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and glucagon receptors that reduced weight and hemoglobin A1c (HbA1c) in individuals with obesity and type 2 diabetes (T2D).