MOTS-c
Also known as: Mitochondrial Open reading frame of the Twelve S rRNA type-c
MOTS-c is an investigational mitochondrial-derived peptide studied preclinically for metabolic regulation. It is research-only and not FDA-approved; the CB4211 analog program (CohBar) was discontinued in 2023.
Who's worth your money for MOTS-c
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 40 scored sellers
$45.99 · 20mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
— · 10mg · 99.8% purity
Most tested
46 independent COAs on file
$46.20 · 20mg · 99.3% purity
Average price
$4.37/mg
Sellers
78
45-day trend
-9%
59 of 78 sellers have a current price· 5 stale hidden· 14 unverified hidden
Top Merit pick
🇺🇸 Glacier Aminos99✓ verified at source · 10h ago
$2.30/mg -47.4% vs avg$45.99
20mg
- 🇺🇸 Peptide Partners99
✓ verified at source · 9h ago
$6.30/mg +44.1% vs avg$252
40mg
- 🇺🇸 Hydro Research Peptides97
✓ verified at source · 9h ago
$3.50/mg -19.9% vs avg$35.00
10mg
- 🇺🇸 BioLongevity Labs96
✓ verified at source · 9h ago
$11.00/mg +151.6% vs avg$110
10mg
- 🇺🇸 Reta One Labs95
✓ verified at source · 9h ago
$2.90/mg -33.7% vs avg$29.00
10mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 10h ago
$3.00/mg -31.4% vs avg$120
40mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 10h ago
$6.50/mg +48.7% vs avg$65.00
10mg
- 🇺🇸 Sunrise Bioresearch94
via Disclosed Labs · 10h ago
$1.66/mg -62% vs avg$166
100mg
- 🇺🇸 Forge Performance Co.94
via Disclosed Labs · 10h ago
$3.00/mg -31.4% vs avg$60.00
20mg
- 🇺🇸 Peptide Crafters94
✓ verified at source · 10h ago
$3.67/mg -16.1% vs avg$55.00
15mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About MOTS-c
CAS
1627580-64-6
Molecular formula
C101H152N28O22S2
Sequence
MRWQEMGYIFYPRKLR
Typical dose range
5–10 mg subcutaneous, 2–3 times per week (research use)
Half-life
~4–6 hours (estimated; exercise-induced endogenous levels return to baseline within ~4 hours)
COAs for MOTS-c
324 third-party tests across 53 vendors. Each card links to the full report.
For
MOTS-C
by jdbioworks· batch 2026-003
For
MOTS-C
by jdbioworks· batch 2026-002
For
MOTS-C
by Verified Peptides· batch M007261420M
For
MOTS-C
by Peptide Plugs· batch 160-04-DK
For
MOTS-C
by Rescue Research USA· batch RR-MS-2607
For
MOTS-C
by Peptide Plugs· batch 149-01-DK
For
MOTS-c
by Arcane Peptides· batch MOT002
For
MOTS-c
by Moglabs· batch MOT002
For
MOTS-c
by Ruo Bio· batch MOT002
For
MOTS-c
by Moglabs· batch MOT002
For
MOTS-c
by Ruo Bio· batch MOT402
For
MOTS-C
by Nova Peptides· batch NV-P-O9NB
For
MOTS-c
by Polaris Peptides· batch POL-M10-8
For
MOTS-C
by NG Peptide· batch MS40-08
For
MOTS-c
by Peptide Crafters· batch PC-G3-MOT15
For
MOTS-c
by Real Peptides· batch RP062326MC
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Apexx Biolabs· batch Light Purple Cap-1
For
MOTS-c
by Real Peptides· batch BATCH-0322
For
MOTS-C
by OROS Research· batch OR-LPMOTS10-626-B8
For
MOTS-C
by Rescue Research USA· batch WP-MS-2606
For
MOTS-C
by Ion Peptide· batch MC40-06032026
For
MOTS-C
by Ion Peptide· batch MCD4-06022026
23 citations indexed for MOTS-c
cohort · Ongoing
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
review · 2026
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential
Sepsis-induced cardiomyopathy (SICM) is a prevalent cardiac complication of sepsis that is characterized by inflammatory dysregulation, mitochondrial dysfunction, metabolic disturbance, and changes in the myocardial microenvironment.
Study · 2026
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide
The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded.
Study · 2026
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
Objective MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men.
animal · 2026
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy.
animal · 2026
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia
Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype.