MOTS-c
Also known as: Mitochondrial Open reading frame of the Twelve S rRNA type-c
MOTS-c is an investigational mitochondrial-derived peptide studied preclinically for metabolic regulation. It is research-only and not FDA-approved; the CB4211 analog program (CohBar) was discontinued in 2023.
Who's worth your money for MOTS-c
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 37 scored sellers
$45.99 · 20mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
— · 10mg · 99.8% purity
Most tested
20 independent COAs on file
$252 · 40mg · 99.2% purity
Average price
$4.66/mg
Sellers
80
45-day trend
-10.9%
56 of 80 sellers have a current price· 3 stale hidden· 16 unverified hidden
Top Merit pick
🇺🇸 Glacier Aminos99✓ verified at source · 1h ago
$2.30/mg -50.6% vs avg$45.99
20mg
- 🇺🇸 Peptide Partners99
✓ verified at source · 3d ago
$6.30/mg +35.2% vs avg$252
40mg
- 🇺🇸 Hydro Research Peptides97
✓ verified at source · just now
$3.50/mg -24.9% vs avg$35.00
10mg
- 🇺🇸 Prime Peptides96
✓ verified at source · just now
$6.00/mg +28.8% vs avg$60.00
10mg
- 🇺🇸 BioLongevity Labs96
✓ verified at source · just now
$11.00/mg +136% vs avg$110
10mg
- 🇺🇸 Reta One Labs95
via Disclosed Labs · 5d ago · stale
$1.38/mg -70.5% vs avg$55.00
40mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 5d ago · stale
$2.50/mg -46.3% vs avg$99.99
40mg
- 🇺🇸 Sunrise Bioresearch95
✓ verified at source · just now
$7.13/mg +52.9% vs avg$285
40mg
- Nova Peptides94
✓ verified at source · 1h ago
$1.25/mg -73.2% vs avg$49.99
40mg
- 🇺🇸 Forge Performance Co.94
via Disclosed Labs · 5d ago · stale
$3.00/mg -35.6% vs avg$60.00
20mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About MOTS-c
CAS
1627580-64-6
Molecular formula
C101H152N28O22S2
Sequence
MRWQEMGYIFYPRKLR
Typical dose range
5–10 mg subcutaneous, 2–3 times per week (research use)
Half-life
~4–6 hours (estimated; exercise-induced endogenous levels return to baseline within ~4 hours)
COAs for MOTS-c
363 third-party tests across 54 vendors. Each card links to the full report.
For
MOTS-C
by Sunrise Bioresearch· batch MOT10SEP26-01
For
MOTS-c
by Sunrise Bioresearch· batch MOT10SEP26-01
For
MOTS-C
by VoriLabs· batch MOT-K2609-A
For
MOTS-C
by Peptide Partners· batch PX-L916
For
MOTS-C
by Forge Performance Co.· batch MOTSC20-2609-01-BLK-SLV
For
MOTS-C
by VeratisBio· batch MOTS0001
For
MOTS-C
by VoriLabs· batch MOT-2608-A
For
MOTS-c
by Frontier Aminos· batch MS40-09
For
MOTS-C
by jdbioworks· batch 2026-003
For
MOTS-C
by NovaForge Labs· batch NFL-0001
For
MOTS-c
by Novaglo Research· batch 5004081226MC
For
MOTS-C
by jdbioworks· batch 2026-002
For
MOTS-C
by Artisan Aminos· batch AA-MOTS10-049
For
MOTS-C
by Artisan Aminos· batch AA-MOTS40-049
For
MOTS-C
by Verified Peptides· batch M007261420M
For
MOTS-c
by CertaPeptides· batch CP-2605-MOT40
For
MOTS-C
by Verified Peptides· batch M007261420M
For
MOTS-C
by Peptide Plugs· batch 160-04-DK
For
MOTS-C
by Rescue Research USA· batch RR-MS-2607
For
MOTS-c
by VoriLabs· batch MOT-2606-A
For
MOTS-C
by Peptide Plugs· batch 149-01-DK
For
MOTS-c
by Arcane Peptides· batch MOT002
For
MOTS-c
by Moglabs· batch MOT002
For
MOTS-c
by Ruo Bio· batch MOT002
23 citations indexed for MOTS-c
cohort · Ongoing
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
review · 2026
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential
Sepsis-induced cardiomyopathy (SICM) is a prevalent cardiac complication of sepsis that is characterized by inflammatory dysregulation, mitochondrial dysfunction, metabolic disturbance, and changes in the myocardial microenvironment.
Study · 2026
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide
The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded.
Study · 2026
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
Objective MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men.
animal · 2026
Mots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease, but current therapies do not halt its progression.
animal · 2026
The Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes
Lay summary As women age, the quality of their eggs declines, which is a major contributor to age-related infertility. Eggs are supported by neighboring "helper" cells called granulosa cells, which act like a support crew that supplies the egg with the energy it needs to mature.