MOTS-c
Also known as: Mitochondrial Open reading frame of the Twelve S rRNA type-c
MOTS-c is an investigational mitochondrial-derived peptide studied preclinically for metabolic regulation. It is research-only and not FDA-approved; the CB4211 analog program (CohBar) was discontinued in 2023.
Who's worth your money for MOTS-c
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 30 scored sellers
$45.99 · 20mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
— · 10mg · 99.8% purity
Most tested
45 independent COAs on file
$77.00 · 20mg · 98.7% purity
Average price
$5.09/mg
Sellers
92
45-day trend
-2.8%
79 of 92 sellers have a current price· 18 stale hidden· 31 unverified hidden
Top Merit pick
🇺🇸 Glacier Aminos99✓ verified at source · 23h ago
$2.30/mg -54.8% vs avg$45.99
20mg
- 🇺🇸 Peptide Partners99
✓ verified at source · 23h ago
$6.30/mg +23.7% vs avg$252
40mg
- 🇺🇸 BioLongevity Labs96
✓ verified at source · 23h ago
$11.00/mg +116% vs avg$110
10mg
- 🇺🇸 Reta One Labs95
✓ verified at source · 23h ago
$1.80/mg -64.7% vs avg$72.00
40mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 23h ago
$3.75/mg -26.4% vs avg$150
40mg
- 🇺🇸 Prime Peptides95
via Disclosed Labs · 23h ago
$5.50/mg +8% vs avg$55.00
10mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 23h ago
$7.60/mg +49.2% vs avg$76.00
10mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · 23h ago
$45.00/mg +783.6% vs avg$450
10mg
- 🇺🇸 Mile High Compounds94
✓ verified at source · 23h ago
$1.25/mg -75.5% vs avg$49.99
40mg
- 🇺🇸 Forge Performance Co.94
✓ verified at source · 23h ago
$3.00/mg -41.1% vs avg$60.00
20mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About MOTS-c
CAS
1627580-64-6
Molecular formula
C101H152N28O22S2
Sequence
MRWQEMGYIFYPRKLR
Typical dose range
5–10 mg subcutaneous, 2–3 times per week (research use)
Half-life
~4–6 hours (estimated; exercise-induced endogenous levels return to baseline within ~4 hours)
COAs for MOTS-c
277 third-party tests across 40 vendors. Each card links to the full report.
For
MOTS-C
by Peptide Plugs· batch 149-01-DK
For
MOTS-c
by Ruo Bio· batch MOT002
For
MOTS-c
by Moglabs· batch MOT002
For
MOTS-c
by Ruo Bio· batch MOT402
For
MOTS-C
by NG Peptide· batch MS40-08
For
MOTS-c
by Real Peptides· batch RP062326MC
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Sunrise Bioresearch· batch MTC10MAY26-02
For
MOTS-C
by Apexx Biolabs· batch Light Purple Cap-1
For
MOTS-c
by Real Peptides· batch BATCH-0322
For
MOTS-C
by Ion Peptide· batch MC40-06032026
For
MOTS-C
by Ion Peptide· batch MCD4-06022026
For
MOTS-C
by Peptide Plugs· batch 127-02-DK
For
MOTS-C
by Peptide Partners· batch SPL-4096
For
MOTS-C
by Voltera Sciences· batch MS40.05.28.26
For
MOTS-C
by Verified Peptides· batch M005261320L
For
MOTS-C
by Crush Research· batch CRMTS-40-2605-2
For
MOTS-C
by Crush Research· batch CR-MOTS20-2605-1
For
MOTS-C
by Crush Research· batch CRMTS-40-2605-1
For
MOTS-C
by Crush Research· batch CRMTS-10-2605-1
For
MOTS-c
by Reta One Labs· batch MTS100626
For
MOTS-C
by Nox Amino· batch NA-MS0226-01
For
MOTS-c
by Blank Peptides· batch B-7058391-P
For
MOTS-C
by NG Peptide· batch MTS40-07
23 citations indexed for MOTS-c
cohort · 2027
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
Study · 2026
Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
Objective MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men.
animal · 2026
MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia
Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype.
Study · 2026
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
Background: Atrial fibrillation (AF) is a common clinical arrhythmia associated with mitochondrial dysfunction, oxidative stress, and atrial fibrosis. Mitochondrial-derived peptides (MDPs), including humanin (HN) and MOTS-c, exhibit cytoprotective properties, but their role in AF remains largely unknown.
Study · 2026
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy.
review · 2026
MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases
Background MOTS-c is a mitochondrial-derived microprotein (mitokine) encoded within the 12 S rRNA gene that exerts intracrine, paracrine, and endocrine effects across multiple tissues.