Matrixyl
Also known as: Palmitoyl Pentapeptide-4, Palmitoyl Pentapeptide-3, Pal-KTTKS, Palmitoyl-Lys-Thr-Thr-Lys-Ser
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a topically applied cosmetic peptide consisting of the matrikine pentapeptide KTTKS — a subfragment of type I procollagen — conjugated to palmitic acid to improve skin penetration. It is marketed to stimulate fibroblast production of collagen, elastin, and other extracellular-matrix components, thereby reducing the appearance of fine lines and wrinkles. In the U.S. it is regulated as a cosmetic ingredient and is NOT an FDA-approved drug.
Who's worth your money for Matrixyl
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (95) of 2 scored sellers
$129 · 10mg · 99.7% purity
Best value
Lowest $/mg among scored sellers
$49.99 · 10mg · 99.1% purity
Average price
$4.93/mg
Sellers
7
45-day trend
+4.7%
4 of 7 sellers have a current price· 2 unverified hidden
Top Merit pick
🇺🇸 Ion Peptide95✓ verified at source · 1h ago
$12.90/mg +161.9% vs avg$129
10mg
- Modern Research Peptides82
✓ verified at source · just now
$5.00/mg +1.5% vs avg$49.99
10mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
Watch Matrixyl
Get one email when the market actually moves — no newsletter, no noise.
About Matrixyl
CAS
214047-00-4
Molecular formula
C39H75N7O10
Sequence
KTTKS
Typical dose range
Topical only; commonly formulated in cosmetics around 3–8% of the supplier's diluted peptide solution. Not dosed systemically.
Half-life
Not well characterized for topical use; subject to dermal peptidase degradation.
Common research uses
Safety notes
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; anti-aging efficacy evidence is limited and largely supplier-derived. Generally well tolerated topically. Not intended for injection. Not a WADA-prohibited substance.
Reconstitution
Supplied as a powder or pre-diluted cosmetic-grade solution for incorporation into topical formulations; not reconstituted for injection.
COAs for Matrixyl
4 third-party tests across 2 vendors. Each card links to the full report.
For
Palmitoyl Pentapeptide-4
by Ion Peptide· batch PP1G-05162026
For
Matrixyl
by Ion Peptide· batch MATRIX-04202026
For
Matrixyl
by Modern Research Peptides· batch MWCHJ462
For
Matrixyl
by Ion Peptide· batch MATRIX-04202026
12 citations indexed for Matrixyl
animal · 2026
Permeation behaviour of cosmetic actives into the human stratum corneum
Characterising the permeation of cosmetic actives through human skin is important for understanding their functional performance.
case-report · 2026
Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis
An increase in wrinkles, laxity, and dyschromia characterizes facial-skin aging. The skin is a natural barrier that prevents or limits the entry of external therapeutic compounds to the body. Enhancing the efficacy of transdermal delivery of anti-aging compounds is a key therapeutic strategy.
review · 2026
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
Study · 2026
Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides
The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl and is used in cosmetic formulations as it can stimulate collagen production.
Study · 2026
A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials
GHK-Cu, the copper-bound form of the human tripeptide glycyl-L-histidyl-L-lysine has accumulated more than four decades of pre-clinical evidence for tissue regeneration, anti-inflammatory action, antioxidant capacity, and broad gene-expression remodeling.
review · 2026
Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials
Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.