LL-37

review · 2026

LL-37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease

Human cathelicidin peptide LL-37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions.

Study · 2026

Coordination chemistry and antimicrobial activity of LL-37, its C-terminal fragment, and a peptidomimetic analogue

Human cathelicidin LL-37 is an antimicrobial peptide naturally present in saliva that plays an important role in host defence against bacterial and fungal pathogens. Although LL-37 is known to bind Cu(II) and Zn(II) ions, the corresponding coordination modes have remained unresolved.

Study · 2026

LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells

BACKGROUND: During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved.

Study · 2026

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection

Oral squamous cell carcinoma (OSCC) is the predominant form of oral malignancy, with late-stage diagnosis contributing to poor prognosis. Oral potentially malignant disorders (OPMDs) often precede OSCC, underscoring the need for early diagnostic biomarkers.

review · 2026

β-Amyloid (Aβ) and Human Cathelicidin LL-37: Two Sides of the Same Coin?

Study · 2026

A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration

Gingival recession exposes the roots, leads to dentin hypersensitivity, and heightens the progression of periodontitis, and poses a threat to oral health and appearance. Conventional treatment uses autogenous palatal grafts, requiring a second surgical site and adding patient discomfort.