Gonadorelin
Also known as: GnRH
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH/LHRH; sequence pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2). It was historically FDA-approved as Factrel (diagnostic GnRH stimulation test) and Lutrepulse (pulsatile IV pump for hypothalamic amenorrhea); both products are discontinued in the US. Gonadorelin remains on the FDA Category 1 bulk substances list and is widely compounded, most commonly as an off-label adjunct to TRT intended to preserve HPG-axis signaling.
Who's worth your money for Gonadorelin
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (82) of 2 scored sellers
$32.99 · 5mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
$75.00 · 2mg
Average price
$11.43/mg
Sellers
13
45-day trend
-3.8%
8 of 13 sellers have a current price· 1 stale hidden· 5 unverified hidden
Top Merit pick
Modern Research Peptides82✓ verified at source · just now
$6.60/mg -42.3% vs avg$32.99
5mg
- 🇺🇸 MedGe Peptides82
✓ verified at source · just now
$37.50/mg +228% vs avg$75.00
2mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
Watch Gonadorelin
Get one email when the market actually moves — no newsletter, no noise.
About Gonadorelin
CAS
33515-09-2
Molecular formula
C55H75N17O13
Sequence
QHWSYGLRPG
Typical dose range
100–250 mcg subcutaneous, 2–3x weekly (research use); 5–20 mcg/pulse every 90–120 min via pulsatile infusion pump for hypogonadotropic hypogonadism
Half-life
Distribution: 2–10 minutes; terminal: 10–40 minutes
COAs for Gonadorelin
7 third-party tests across 4 vendors. Each card links to the full report.
For
Gonadorelin
by VoriLabs· batch GONA-A2609-A
For
Gonadorelin
by Kimera Chems· batch KC-GON-PNK1
For
Gonadorelin
by Peptidology· batch 1671
For
Gonadorelin
by Modern Research Peptides· batch HKGN526012
For
Gonadorelin
by Soma Peptides· batch GOII042562
For
Gonadorelin
by Kimera Chems· batch Yellow Cap
Purity not on file
For
Gonadorelin
by EZ Peptides· batch JMSPD751
20 citations indexed for Gonadorelin
review · 2026
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review
Introduction Peptide-based therapies are increasingly used in urology and sexual medicine, although adoption is often influenced by off-label prescribing, direct-to-consumer promotion, and limited long-term safety data. We review mechanisms, clinical evidence, dosing, safety, and regulatory status of these agents.
Study · 2026
Effects of high frequency administration of GnRH or kisspeptin on LH pulse and surge profiles in ovariectomized Bos taurus and Bos indicus heifers†
We hypothesized that high-frequency stimulation with kisspeptin or GnRH, mimicking increased GnRH pulsatility, would amplify the GnRH-induced LH surge in heifers. Additionally, LH pulse and surge parameters were compared between Bos taurus and Bos indicus heifers.
Study · 2026
Diagnostic Usefulness of Subcutaneous Triptorelin Stimulation Testing in the Evaluation of Central Precocious Puberty in Girls
The limited availability of gonadorelin has resulted in an increased use of subcutaneous triptorelin to diagnose central precocious puberty; however, studies validating its diagnostic value remain limited.
Study · 2026
Progesterone feedback effects on LH pulse and surge secretion in ovariectomized Bos taurus, Bos indicus and crossbred heifers
This study evaluated the effects of progesterone (P4) on LH pulse and surge secretion, and hypothalamic neuroendocrine differences between Bos indicus, Bos taurus, and crossbred heifers.
animal · 2026
Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes
The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the day of initiation of the synchronization protocol (SYNCd), at the day of embryo transfer (ETd), or at both time points using a 2 × 2 experimental arrangement in Holstein heifer recipients.
animal · 2026
Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows
The objective of this study was to evaluate the effect of administering 200 µg versus 100 µg of GnRH as gonadorelin hydrochloride (Factrel; Zoetis, Parsippany, NJ) at the first GnRH injection (G1) of the breeding Ovsynch in a Double-Ovsynch (DO) protocol on pregnancy per artificial insemination (P/AI) at first service…