Epithalon
Also known as: Epitalon (AEDG, synthetic analog of Epithalamin)
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Khavinson as an analog of the bovine pineal extract Epithalamin. It is a research-only bioregulator — not FDA-approved — investigated for claimed telomerase activation and circadian/melatonin effects, with evidence limited primarily to Khavinson-group studies.
Who's worth your money for Epithalon
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 20 scored sellers
$792 · 400mg · 99.9% purity
Best value
Lowest $/mg among scored sellers
$450 · 500mg · 99.6% purity
Most tested
24 independent COAs on file
$33.00 · 10mg · 99.6% purity
Average price
$3.40/mg
Sellers
77
45-day trend
-17.5%
64 of 77 sellers have a current price· 21 stale hidden· 23 unverified hidden
Top Merit pick
🇺🇸 Peptide Partners99via Disclosed Labs · 23h ago
$1.98/mg -41.8% vs avg$792
400mg
- 🇺🇸 Glacier Aminos99
✓ verified at source · 23h ago
$3.30/mg -3.1% vs avg$32.99
10mg
- 🇺🇸 BioLongevity Labs96
✓ verified at source · 23h ago
$4.75/mg +39.5% vs avg$94.97
20mg
- 🇺🇸 Profound Aminos95
via Disclosed Labs · 23h ago
$3.70/mg +8.7% vs avg$37.00
10mg
- 🇺🇸 Orbitrex Peptides95
via Disclosed Labs · 23h ago
$4.00/mg +17.5% vs avg$39.99
10mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · 23h ago
$9.20/mg +170.2% vs avg$91.99
10mg
- 🇺🇸 Peptide Tech94
✓ verified at source · 23h ago
$3.50/mg +2.8% vs avg$34.99
10mg
- 🇺🇸 Hydro Research Peptides91
✓ verified at source · 23h ago
$4.50/mg +32.2% vs avg$45.00
10mg
- 🇺🇸 Verified Peptides86
via Disclosed Labs · 23h ago
$3.30/mg -3.1% vs avg$33.00
10mg
- 🇺🇸 Simple Peptide85
✓ verified at source · 23h ago
$3.30/mg -3.1% vs avg$33.00
10mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Epithalon
CAS
307297-39-8
Molecular formula
C14H22N4O9
Sequence
AEDG
Typical dose range
5–10 mcg/day subcutaneous or intranasal, typically in cycles of 10–20 days; human clinical studies used 0.5 mg/day sublingually or 5 mcg parabulbarly
Half-life
~30 minutes (estimated; formal pharmacokinetic data limited in published literature)
COAs for Epithalon
111 third-party tests across 26 vendors. Each card links to the full report.
For
Epithalon
by Ion Peptide· batch EP50-02032026
For
Epithalon
by Ion Peptide· batch ET50-06242026
For
Epithalon
by Ion Peptide· batch ET50-06242026
For
Epithalon
by Profound Aminos· batch Blue Cap
For
Epithalon
by OROS Research· batch OR-LPEPI10-526-B2
For
Epithalon
by Profound Aminos
For
Epithalon
by Peptide Partners· batch ET202604
For
Epithalon
by Crush Research· batch CRET-50-0212-1
For
Epithalon
by Ion Peptide· batch ET50-05042026
For
Epithalon
by NG Peptide· batch EP50-06
For
Epithalon
by BioLongevity Labs· batch 9-3-46146
For
Epithalon
by Real Peptides· batch Orange Cap
For
Epithalon
by Verified Peptides· batch cmp4wgbkb004jx7rxdpeilkwp
For
Epithalon
by Verified Peptides· batch cmp4wgbn6004kx7rx72c6lhyu
For
Epithalon
by Verified Peptides· batch cmp4wgbpl004lx7rxfa45zj6b
For
Epithalon
by Peptide Plugs· batch 115-B-DK
For
Epithalon
by Qihang Peptide· batch 4
For
Epithalon
by OROS Research· batch OR-LPEPI10-326-B2
For
Epithalon
by Glacier Aminos· batch EPI10GA-02
For
Epithalon
by Amino Club· batch EPI0001
For
Epithalon
by Peptidology· batch 1673
For
Epithalon
by Ion Peptide· batch ET10-03102026
For
Epithalon 10mg
by Ion Peptide· batch ET10-02232026
For
Epithalon
by Crush Research· batch CR-ET40-0217-1
12 citations indexed for Epithalon
review · 2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
review · 2026
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.
meta-analysis · 2026
Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background Migraine is a chronic, disabling brain disorder. Melatonin, a circadian regulator with anti-inflammatory and antinociceptive actions, has been proposed for migraine prevention. We evaluated the efficacy and safety of melatonin for prophylaxis.
review · 2025
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution.
Study · 2025
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases.
review · 2024
[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]
The review presents the results of long-term research conducted by the staff of the Saint-Petersburg Institute of Bioregulation and Gerontology, dedicated to the study of the biological activity of peptide bioregulators at all levels of a living organism's organization.