Dihexa
Also known as: PNB-0408
Dihexa (PNB-0408) is a small-molecule hexapeptide-like analog of angiotensin IV developed at Washington State University by the Harding/Wright group as a preclinical candidate for Alzheimer's disease and cognitive decline. It is NOT FDA-approved and has never been tested in human clinical trials. The often-quoted claim that it is 'roughly ten million times more potent than BDNF' refers to EC50 comparisons in an in vitro dendritic spine assay, not clinical efficacy.
Who's worth your money for Dihexa
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (96) of 4 scored sellers
$40.00 · 150mg · 99.6% purity
Best value
Lowest $/mg among scored sellers
$69.99 · 10mg
Most tested
2 independent COAs on file
$130 · 10mg
Average price
$10.44/mg
Sellers
21
45-day trend
-13.5%
11 of 21 sellers have a current price· 3 stale hidden· 4 unverified hidden
Top Merit pick
🇺🇸 Moglabs96via Disclosed Labs · 23h ago
$0.27/mg -97.4% vs avg$40.00
150mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · 6d ago · stale
$13.00/mg +24.5% vs avg$130
10mg
- 🇺🇸 Peptidology89
✓ verified at source · 23h ago
$7.00/mg -33% vs avg$69.99
10mg
no purity - Nextech Labs24
✓ verified at source · 23h ago
$22.50/mg +115.4% vs avg$90.00
4mg
no purity
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
Watch Dihexa
Get one email when the market actually moves — no newsletter, no noise.
About Dihexa
CAS
1401708-83-5
Molecular formula
C27H44N4O5
Typical dose range
2-5 mg/day subcutaneous or 10-40 mg/day oral/intranasal; typical research cycles 4-6 weeks on with 2-4 weeks off
Half-life
12.68 days (i.v., rat); 8.83 days (i.p., rat); ~2-4 hours estimated for oral/intranasal routes
COAs for Dihexa
10 third-party tests across 5 vendors. Each card links to the full report.
For
Dihexa
by Moglabs· batch DIH001
For
Dihexa
by Moglabs· batch DIH001
For
Dihexa
by Ruo Bio· batch DIH001
For
Dihexa
by BioLongevity Labs· batch cmojb7lwg01cqkirxjd6royw0
For
Dihexa
by Kimera Chems· batch KC-DHX-02
Purity not on file
For
Dihexa
by Licensed Peptides· batch 26126001
Purity not on file
For
Dihexa
by Licensed Peptides· batch 26126001
Purity not on file
For
Dihexa
by Skye Peptides· batch 01DXA25
Purity not on file
For
DIHEXA
by Moglabs
Purity not on file
For
Dihexa
by Ruo Bio
12 citations indexed for Dihexa
review · 2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
animal · 2026
Umbilical cord mesenchymal stromal cells-derived HGF inhibits STING-mediated pyroptosis to alleviate cerebral ischemia/reperfusion injury via c-Met/β-catenin/RNF5 pathway
BACKGROUND: Pyroptosis plays an essential role in the pathological process of cerebral ischemia/reperfusion (I/R) injury. Hepatocyte growth factor (HGF)-modified stem cells improve brain I/R damage.
in-vitro · 2025
Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cells
The growth factor and small molecule protocol are the two primary approaches for generating human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs). We compared the efficacy of the growth factor and small molecule protocols across fifteen different human iPSC lines.
animal · 2025
Generation and applications of an expandable and mature hiPSC-derived liver organoid
Organoids have emerged as a powerful tool for modeling liver diseases, drug screening, and personalized treatments. However, they have a limited capacity to generate functional hepatocytes in a reproducible and efficient manner.
Study · 2025
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories
In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.
animal · 2024
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
Background Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric dysfunction caused by a mutant huntingtin protein.