Dihexa
Also known as: PNB-0408
Dihexa (PNB-0408) is a small-molecule hexapeptide-like analog of angiotensin IV developed at Washington State University by the Harding/Wright group as a preclinical candidate for Alzheimer's disease and cognitive decline. It is NOT FDA-approved and has never been tested in human clinical trials. The often-quoted claim that it is 'roughly ten million times more potent than BDNF' refers to EC50 comparisons in an in vitro dendritic spine assay, not clinical efficacy.
Who's worth your money for Dihexa
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Top Merit pick
Highest Merit Score (99) of 9 scored sellers
$99.99 · 5mg
Best value
Lowest $/mg among scored sellers
$180 · 50mg
Average price
$11.03/mg
Sellers
23
45-day trend
-14.8%
14 of 23 sellers have a current price· 1 stale hidden· 4 unverified hidden
Top Merit pick
🇺🇸 Glacier Aminos99✓ verified at source · 1h ago
$20.00/mg +81.2% vs avg$99.99
5mg
- 🇺🇸 Moglabs98
✓ verified at source · just now
$8.00/mg -27.5% vs avg$40.00
5mg
- 🇺🇸 Licensed Peptides95
✓ verified at source · just now
$13.00/mg +17.8% vs avg$130
10mg
- 🇺🇸 Certified Peptides94
✓ verified at source · 1h ago
$3.60/mg -67.4% vs avg$180
50mg
no purity - 🇺🇸 Ruo Bio88
✓ verified at source · just now
$7.20/mg -34.7% vs avg$36.00
5mg
- 🇺🇸 OROS Research79
✓ verified at source · 1d ago
$14.50/mg +31.4% vs avg$145
10mg
no purity - 🇺🇸 Genetic Peptide70
✓ verified at source · just now
$10.00/mg -9.4% vs avg$100
10mg
- Nextech Labs38
✓ verified at source · just now
$18.00/mg +63.1% vs avg$90.00
5mg
no purity - 🇺🇸 AMC Essentials30
✓ verified at source · just now
$8.00/mg -27.5% vs avg$39.99
5mg
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Dihexa
CAS
1401708-83-5
Molecular formula
C27H44N4O5
Typical dose range
2-5 mg/day subcutaneous or 10-40 mg/day oral/intranasal; typical research cycles 4-6 weeks on with 2-4 weeks off
Half-life
12.68 days (i.v., rat); 8.83 days (i.p., rat); ~2-4 hours estimated for oral/intranasal routes
COAs for Dihexa
12 third-party tests across 7 vendors. Each card links to the full report.
For
Dihexa
by Moglabs· batch DIH001
For
Dihexa
by Moglabs· batch DIH001
For
Dihexa
by Ruo Bio· batch DIH001
For
Dihexa
by BioLongevity Labs· batch cmojb7lwg01cqkirxjd6royw0
For
Dihexa
by Kimera Chems· batch KC-DHX-02
Purity not on file
For
Dihexa
by Glacier Aminos· batch DICAPGA-01
Purity not on file
For
Dihexa
by Licensed Peptides· batch 26126001
Purity not on file
For
Dihexa
by Licensed Peptides· batch 26126001
Purity not on file
For
Dihexa
by Genetic Peptide· batch A22250127
Purity not on file
For
Dihexa
by Skye Peptides· batch 01DXA25
Purity not on file
For
DIHEXA
by Moglabs
Purity not on file
For
Dihexa
by Ruo Bio
12 citations indexed for Dihexa
review · 2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
animal · 2026
Umbilical cord mesenchymal stromal cells-derived HGF inhibits STING-mediated pyroptosis to alleviate cerebral ischemia/reperfusion injury via c-Met/β-catenin/RNF5 pathway
BACKGROUND: Pyroptosis plays an essential role in the pathological process of cerebral ischemia/reperfusion (I/R) injury. Hepatocyte growth factor (HGF)-modified stem cells improve brain I/R damage.
Study · 2025
Hepatocyte Growth Factor/MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) can produce persistent cognitive and behavioral deficits. These impairments result in a reduced quality of life and difficulty returning to work, school, or other activities.
in-vitro · 2025
Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cells
The growth factor and small molecule protocol are the two primary approaches for generating human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs). We compared the efficacy of the growth factor and small molecule protocols across fifteen different human iPSC lines.
animal · 2025
Generation and applications of an expandable and mature hiPSC-derived liver organoid
Organoids have emerged as a powerful tool for modeling liver diseases, drug screening, and personalized treatments. However, they have a limited capacity to generate functional hepatocytes in a reproducible and efficient manner.
Study · 2025
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories
In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.