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Nootropic / Cognitive

Dihexa

Also known as: PNB-0408

Dihexa (PNB-0408) is a small-molecule hexapeptide-like analog of angiotensin IV developed at Washington State University by the Harding/Wright group as a preclinical candidate for Alzheimer's disease and cognitive decline. It is NOT FDA-approved and has never been tested in human clinical trials. The often-quoted claim that it is 'roughly ten million times more potent than BDNF' refers to EC50 comparisons in an in vitro dendritic spine assay, not clinical efficacy.

Where to buy · live market data

Who's worth your money for Dihexa

Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.

Top Merit pick

Highest Merit Score (96) of 4 scored sellers

$0.27/mg

$40.00 · 150mg · 99.6% purity

Best value

Lowest $/mg among scored sellers

$7.00/mg

$69.99 · 10mg

no COAs yet

Most tested

2 independent COAs on file

$13.00/mg

$130 · 10mg

2 COAs
Buy code MERIT · 5% off

Average price

$10.44/mg

Sellers

21

45-day trend

-13.5%

11 of 21 sellers have a current price· 3 stale hidden· 4 unverified hidden

Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.

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Compound reference

About Dihexa

CAS

1401708-83-5

Molecular formula

C27H44N4O5

Typical dose range

2-5 mg/day subcutaneous or 10-40 mg/day oral/intranasal; typical research cycles 4-6 weeks on with 2-4 weeks off

Half-life

12.68 days (i.v., rat); 8.83 days (i.p., rat); ~2-4 hours estimated for oral/intranasal routes

Research depth

12 citations indexed for Dihexa

All research on Dihexa →

review · 2026

Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.

animal · 2026

Umbilical cord mesenchymal stromal cells-derived HGF inhibits STING-mediated pyroptosis to alleviate cerebral ischemia/reperfusion injury via c-Met/β-catenin/RNF5 pathway

BACKGROUND: Pyroptosis plays an essential role in the pathological process of cerebral ischemia/reperfusion (I/R) injury. Hepatocyte growth factor (HGF)-modified stem cells improve brain I/R damage.

in-vitro · 2025

Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cells

The growth factor and small molecule protocol are the two primary approaches for generating human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs). We compared the efficacy of the growth factor and small molecule protocols across fifteen different human iPSC lines.

animal · 2025

Generation and applications of an expandable and mature hiPSC-derived liver organoid

Organoids have emerged as a powerful tool for modeling liver diseases, drug screening, and personalized treatments. However, they have a limited capacity to generate functional hepatocytes in a reproducible and efficient manner.

Study · 2025

The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories

In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.

animal · 2024

Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats

Background Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric dysfunction caused by a mutant huntingtin protein.