Argireline
Also known as: Acetyl Hexapeptide-8, Acetyl Hexapeptide-3, Ac-EEMQRR-NH2
Argireline is a synthetic, topically applied cosmetic hexapeptide (N-acetylated, C-terminal amide; Ac-EEMQRR-NH2) corresponding to the N-terminal fragment (residues 12–17) of the SNARE protein SNAP-25. It is marketed as an anti-wrinkle agent that competitively interferes with SNARE complex assembly, attenuating catecholamine and acetylcholine release and thereby reducing the muscle contractions that drive expression lines — a botulinum-toxin-like mechanism but far weaker. In the U.S. it is regulated as a cosmetic ingredient, not as an FDA-approved drug.
Who's worth your money for Argireline
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Average price
$0.49/mg
Sellers
6
45-day trend
building…
1 of 6 sellers have a current price· 1 stale hidden
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Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Argireline
CAS
616204-22-9
Molecular formula
C35H62N14O11S
Sequence
EEMQRR
Typical dose range
Topical only; formulated in cosmetics at roughly 5–10% of the supplier's peptide solution (which is itself dilute), applied to the skin. Not dosed systemically.
Half-life
Not well characterized for topical use; peptide is subject to dermal peptidase degradation.
Common research uses
Safety notes
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; cosmetic anti-aging efficacy claims rest on limited, mostly manufacturer-funded studies. Generally well tolerated topically, with occasional mild local irritation. Not intended for injection. Not a WADA-prohibited substance.
Reconstitution
Supplied as a water-soluble powder or pre-diluted solution for incorporation into topical formulations; not reconstituted for injection.
COAs for Argireline
1 third-party test across 1 vendor. Each card links to the full report.
18 citations indexed for Argireline
animal · 2026
Effects of Botulinum Toxin Type A and Argireline on Dermal Collagen Remodeling and Skin Biology in a Flap Model
Background Botulinum toxin type A (BoNT-A) is increasingly recognized for tissue-level effects beyond neuromuscular blockade, but its impact on dermal collagen composition remains incompletely characterized.
Study · 2026
NoTox Tweakments: Evidence for Topical Neurocosmetic Peptides as Needle‐Free Neuromodulators for Facial Wrinkle Reduction—A Systematic Review
Study · 2026
Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation
Objective The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and α…
Study · 2026
DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging
Skin aging involves complex mechanisms such as overactivation of neuromuscular signals and oxidative stress.
review · 2026
Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials
Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.
animal · 2025
BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model
Background Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.