Argireline
Also known as: Acetyl Hexapeptide-8, Acetyl Hexapeptide-3, Ac-EEMQRR-NH2
Argireline is a synthetic, topically applied cosmetic hexapeptide (N-acetylated, C-terminal amide; Ac-EEMQRR-NH2) corresponding to the N-terminal fragment (residues 12–17) of the SNARE protein SNAP-25. It is marketed as an anti-wrinkle agent that competitively interferes with SNARE complex assembly, attenuating catecholamine and acetylcholine release and thereby reducing the muscle contractions that drive expression lines — a botulinum-toxin-like mechanism but far weaker. In the U.S. it is regulated as a cosmetic ingredient, not as an FDA-approved drug.
Who's worth your money for Argireline
Every current seller, ranked by independent evidence — Merit Score, latest COA purity, and live $/mg (size-normalized). Prices refresh daily. Rankings are never paid.
Average price
$0.49/mg
Sellers
6
45-day trend
0%
1 of 6 sellers have a current price· 1 stale hidden
- No fresh prices — all 1 listing are older than 7 days.
Prices observed from public storefronts (last 24h), normalized to $/mg. "Evidence" is Merit's 0–100 Merit Score, derived only from observable verification evidence (methodology on /about); "Purity" is the latest independent COA. Some buy links are affiliate links — Merit may earn a commission at no extra cost to you, and where a vendor offers one, the code shown gets you a discount at their checkout. Affiliate status never affects price data, ranking, or the Merit Score (full policy on /disclosure). Research use only.
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About Argireline
CAS
616204-22-9
Molecular formula
C35H62N14O11S
Sequence
EEMQRR
Typical dose range
Topical only; formulated in cosmetics at roughly 5–10% of the supplier's peptide solution (which is itself dilute), applied to the skin. Not dosed systemically.
Half-life
Not well characterized for topical use; peptide is subject to dermal peptidase degradation.
Common research uses
Safety notes
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; cosmetic anti-aging efficacy claims rest on limited, mostly manufacturer-funded studies. Generally well tolerated topically, with occasional mild local irritation. Not intended for injection. Not a WADA-prohibited substance.
Reconstitution
Supplied as a water-soluble powder or pre-diluted solution for incorporation into topical formulations; not reconstituted for injection.
COAs for Argireline
1 third-party test across 1 vendor. Each card links to the full report.
18 citations indexed for Argireline
Study · 2026
Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation
Objective The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and α…
Study · 2026
DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging
Skin aging involves complex mechanisms such as overactivation of neuromuscular signals and oxidative stress.
review · 2026
Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials
Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.
cohort · 2026
Transdermal Delivery of Botulinum Toxin for the Management of Oily and Acne-Prone Skin Using TDA Technology
Background Intradermal botulinum toxin injections have been shown to reduce sebaceous gland activity and improve skin texture in patients with oily and acne-prone skin. However, needle-based application is associated with discomfort and potential side effects.
animal · 2025
BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model
Background Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.
review · 2025
Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers
Today's consumer perception and expectations of personal care have gone beyond merely cleansing, moisturizing, and makeup products, focusing more on the reduction or elimination of signs of aging.